Bodies immune system all must eventually take over management of infections such as Lyme disease. In my experience, antibiotics equalize the reduction of bacteria, leaving the work sustainable recovery of our own immune system. Without its own part bodyBЂ ™ s immune vigilance progression of health slowly and painfully. Our understanding of how the immune system and organs of the immune system develops and every recent studies cast light spot on the 2010 health impact of the gastrointestinal tract on the ability of the immune system to function effectively. In this first of a series of three sections we consider the recent understanding of the enormous role the intestine plays in the health of the immune system. Part two will discuss the evaluation and testing of immune dysfunction caused by gastro-intestinal tract. The third part will put it all together to strengthen the immune system. There are about 100 trillion bacteria in the human intestine. It is 10 times more cells, then that is the body. The presence of these bacteria is immunological effect on the rest of the body. In most cases, this immunological effect is very useful. However, this disruption of normal microflora, if not accept, is anti-inflammatory and may be more harmful. Antibiotics can not distinguish between beneficial and harmful bacteria, and therefore contributes to the regulation of healthy bacterial flora. Expression of a bacterial and inflammatory breach of Klebsiella in ankylosing spondylitis, Citrobacter and Klebsiella with rheumatoid arthritis, Yersinia with thyroiditis, Escherichia coli and Proteus with autoimmune diseases. These examples may not be direct impact, and molecular mimicry taking. In addition to the disruption of normal flora, diet is another key factor in overall health of the gastrointestinal tract, and then the reaction is an important component of the innate immune response to intestinal behalf of GALT lymphoid tissue. Food sensitivity is a direct result of the GALT response to Assult and harder than the dimension of a typical antibody titer. Most foods contain lectins, specialized proteins that may be inflammatory for the individual without causing classical antibodies. high levels of lectins are grains, legumes (ie "bean", including peanuts), dairy products and plant family Solanaceae. Many other foods contain lectins, but not so well studied and the number of lectins are not currently considered as high or potentially toxic. Other inflammatory triggers innate immune response, described below, is a pathogen associated molecular models (PAMPs particularly LPS = endotoxin), injury, damage associated molecular model (DAMPS-intracellular components), the end products of deep hlikirovaniya (APE), free radicals, and toxins
The culmination of these inflammatory triggers occurs in the gastrointestinal tract and lead to measurable systemic inflammatory response. The integrity of the cellular lining of intestinal epithelium of the mucous membranes, changes due to this inflammation leads to what is known as a syndrome resulting intestines. Bowel syndrome is pitted central antetsedent wide range of disorders associated with chronic inflammatory condition. endocrine network of intestinal epithelial barrier of tight intercellular connections, controls the balance between immunity tolerancand not >> << self-antigens.
autoimmune disease can occur. This review is timely, given the increased interest in the role of the intestine resulting in the pathogenesis of gastrointestinal diseases and the emergence of new treatment strategies such as probiotics. BЂ "(Nature Clinical Practice Gastroenterology and Hepatology, September 2005, Volume 2 number 9). In short, the immune system is divided into innate and adaptive response. Congenital response, usually within 0-96 hours. It is divided into 2 groups. One group is induced and / or nonspecific. Another group, in general, specifically. This is commonly a group contains a large list of immune responses, including macrophages, mast cells, cytokines, complement system, poly-morphular nucleosides, antimicrobial peptide, natural killer cells and dendritic cells. Adaptive response is usually activated within 4-5 days. Adapted system characteristic forms antibodies that provides sustainable response to repeated infection. This is a very specific system evolved that specializes in effecter T cells and B-lymphocytes. Information, including T cells and B cells use to distinguish derived from dendritic cells of the immune system. Dendritic cells controls XXXXXXXXXXXXX
B-cell response is known as humoral mediated system. It is in this system, in which antibodies to specific protein or infection formed. T-cell lymphocytes, also known as cellular systems. Dendritic cells in response to targeted previously described triggers. This dendritic primer will get different sets of T cells by converting instructions natsYive Th0 cells into Th1, Th2, Th17 and T regulatory cells. Depending on the signaling path can be redirected to give a different answer. This is the most dramatic for people with significant allergies and major infections that affect the efficiency of the immune system to cope with infection. For modulation or balance routes over-reaction and itBЂ ™ with drainage complications decresased. Th1 cells produce cytokines involved more cellular immunity and delayed hypersensitivity reaction. It does this by increasing the cellular activation of macrophages and neutrophils. The more prevailing disease seen with Th1 is rheumatoid arthritis, multiple sclerosis, thyroiditis, Lyme arthritis and Crohn's disease. Th2 cells produce cytokines that are associated with subsequent activation of cell and as a result of allergy anti-body response. It does this with a set of mast cells, basophils and eosinophils. The more prevailing disease is seen with Th2 allergic diseases, bronchial asthma, contact dermatitis, scleroderma, ulcerative colitis and systemic lupus erythematosus. Th17 intermediate GI mucosal immunity and pulmonary pathogens (especially fungi and Gram-negative). This is a major factor of chronic inflammation. It is the main driver to initiate the inflammation of tissues and organs in autoimmune diseases (multiple sclerosis, Crohn's disease, ulcerative colitis, systemic lupus erythematosus, rheumatoid arthritis, scleroderma, alkylosing spondylitis), Lyme arthritis, cancer and transplant rejection and allergy. As mentioned earlier, the gastrointestinal tract is a complete sensitivity of food and bacteria. In most cases, the immune system can recognize and move without the harmful bacteria. It does this by means of innate immune response. This is when harmful bacteria or fungi, inflammatory reaction, which can not be completely excluded that the ongoing inflammatory response has been received. If this continued inflammatory reaction does not turn off, then lasix 30 mg jump to the next level of chronic inflammation. This next level of chronic inflammation has many facets. It includes bowel syndrome and follow the regulation of inflammatory immune profile systemBЂ ™ s. You can also develop an autoimmune response, which is to reduce a recognition, continuing imbalance in TH1/TH2/TH17 lymphocytes and depletion of natural killer cells that may lead to an increase in chronic diseases and cancer. Most chronic diseases have been linked to excessive or persistent inflammation. This is a chronic inflammatory systemic effects of local manifestations. Chronic inflammation occurs when the current injury or susceptible immune system is not counter-regulation. In order to properly manage Lyme disease the immune system must be optimized. The first direction is the optimization of the gastrointestinal tract. In the next issue will focus on evaluation and testing of immune regulation as it relates to the gastrointestinal tract. .
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